Aqueous α‐Arylation of Mono‐ and Diarylethanone Enolates at Low Catalyst Loading,Advanced Synthesis & Catalysis

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Aqueous α‐Arylation of Mono‐ and Diarylethanone Enolates at Low Catalyst Loading
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-07 , DOI: 10.1002/adsc.201701596
Iratxe Astarloa ₁ , Raul SanMartin ₁ , María Teresa Herrero ₁ , Esther Domínguez ₁

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Acetophenone and deoxybenzoin derivatives are selectively α‐arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di‐ and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram‐scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI‐MS spectrometry is also provided.

中文翻译：

低催化剂负荷下单和二芳酮醇烯醇盐的α-芳基化水溶液

苯乙酮和脱氧安息香衍生物通过使用极少量的乙酸钯和二苯膦氧化物作为催化剂体系，而水作为唯一溶剂，选择性地进行α-芳基化。分离出的目标二-和三芳基酮几乎不含金属残留物，反应量可达到克级。还提供了基于TEM图像，中毒实验，动力学图和ESI-MS光谱的机械方案。

更新日期：2018-03-07

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