当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Acid‐Promoted Cascade Cyclization to Produce 2‐(4′‐Alkoxyaryl)‐3,4‐Fused Tricyclic Dihydrobenzopyrans via a Vinylidene para‐Quinone Methide Intermediate
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-04-19 , DOI: 10.1002/ejoc.201800013
Dongil Choi 1 , Naoki Shiga 1 , Robert Franzén 2 , Tetsuhiro Nemoto 1, 3
Affiliation  

We developed a novel method for synthesizing 2‐(4‐hydroxyaryl)‐3,4‐fused tricyclic dihydrobenzopyrans with 2,3‐syn and 3,4‐syn motifs based on the acid‐promoted cascade cyclization via vinylidene para‐quinone methide intermediates. The developed method provided new access to potent and selective ERβ agonists from a simple linear substrate in a single‐step reaction.
image


中文翻译:

酸促进的级联环化反应,通过亚乙烯基对苯醌甲硫氨酸中间体生产2-(4'-烷氧基芳基)-3,4-融合的三环二氢苯并吡喃

我们开发了一种新的方法,该方法基于通过亚乙烯基甲基苯二甲酰甲基中间体的酸促进级联环化反应,合成具有2,3- syn和3,4- syn基序的2-(4-羟基芳基)-3,4-稠合的三环二氢苯并吡喃。 。所开发的方法提供了从简单线性底物在一步反应中获得有效和选择性ERβ激动剂的新途径。
图像
更新日期:2018-04-19
down
wechat
bug