Unprecedented Ester–Amide Exchange Reaction Using Highly Versatile Two-Dimensional Graphene Oxide Supported Base Metal Nanocatalyst,Industrial & Engineering Chemistry Research

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Unprecedented Ester–Amide Exchange Reaction Using Highly Versatile Two-Dimensional Graphene Oxide Supported Base Metal Nanocatalyst
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1021/acs.iecr.8b00498
Rakesh K. Sharma ₁ , Aditi Sharma ₁ , Shivani Sharma ₁ , Sriparna Dutta ₁

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The present study is the first report of an atom economical and environmentally benign amidation of unactivated esters wherein a novel and highly versatile graphene oxide based cobalt nanocatalytic system has been effectively exploited for the synthesis of pharmaceutically significant amide derivatives under neutral reaction conditions. Experimental results revealed that the developed catalyst not only possesses immense potential to accelerate ester amide exchange reaction in the absence of any additives but also exhibits several remarkable attributes like wide functional group tolerance, durability, high turnover numbers, improved yield, and recycling and reusability for subsequent runs without any discernible loss in the catalytic activity. The enhanced catalytic performance may be attributed to the structure of 2-D graphene oxide based material which provides space between graphitic overlayers and metal surfaces making it work like a nanoreactor to expedite ester amide exchange reaction.

中文翻译：

使用高度通用的二维氧化石墨烯负载的贱金属纳米催化剂进行前所未有的酯-酰胺交换反应

本研究是未活化酯的原子经济和环境友好的酰胺化反应的第一份报告，其中一种新型且高度通用的基于氧化石墨烯的钴纳米催化系统已被有效地开发用于在中性反应条件下合成药学上重要的酰胺衍生物。实验结果表明，开发的催化剂在不存在任何添加剂的情况下，不仅具有加速酯酰胺交换反应的巨大潜力，而且还具有多种显着的特性，如宽官能团耐受性，耐用性，高周转率，提高的收率以及可循环使用和可重复使用随后的运行，催化活性没有任何明显的损失。

更新日期：2018-02-28

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