Whether a proportional reduction in the volume of breast tissue proportionately reduces the risk of developing breast cancer has been seriously debated in light of the recognition that most patients undergoing prophylactic mastectomy have residual breast tissue, including terminal ductal units in the skin flaps.^1,2 Animal studies³ from 1986 suggested that the risk of developing mammary tumors was not proportionately reduced by the amount of breast tissue removed. Thus, it was recommended that if absolute protection was desired, a total mastectomy, including the nipple-areolar complex, was required.³

中文翻译：

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什么时候一个小乳房组织太多？减少BRCA携带者乳头的降低风险的乳房切除术

认识到大多数接受预防性乳房切除术的患者都有残留的乳房组织，包括皮瓣中的末端导管，因此，对乳房组织体积的按比例减少是否会成比例地降低患乳腺癌的风险进行了认真的辩论。^{1 ，2}动物研究³从1986年提出，显影乳腺肿瘤的风险没有被去除的乳房组织的量成比例地减少。因此，建议如果需要绝对保护，则需要进行全乳切除，包括乳头-乳晕复合体。³