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Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-02-20 , DOI: 10.1016/j.jff.2018.02.012
Carlos Martins-Gomes , Meriem Taghouti , Judith Schäfer , Mirko Bunzel , Amélia M. Silva , Fernando M. Nunes

Thymus carnosus Boiss. is an endangered species endemic to Portugal. Studies on its phytochemical composition and bioactivity would increase its use and protection, as no data is available. LC-MS analysis of T. carnosus decoction and hydroethanolic extracts allowed the identification of a salvianolic A isomer, which has not been described in Thymus genus before, rosmarinic and salvianolic K acids as the main phenolics. Luteolin, apigenin and eriodictyol glycosides were identified in lower amounts. Oleanolic and ursolic acids were present only in hydroethanolic extracts. Decoction extracted 32.4% of the phenolic compounds obtained by exhaustive hydroethanolic extraction. Both extracts reduced the viability of three cancer cell lines (human breast: MCF-7, BT-474; murine macrophage: Raw 264.7), with hydroethanolic extracts showing a higher activity. T. carnosus extracts possess significant antioxidant, anti-inflammatory and anti-proliferative activities and may be suggested as a new potential source of natural antioxidants and their decoctions as a novel functional food.



中文翻译:

百里香胸腺汤和水乙醇提取物的化学表征和生物活性。

胸腺肉蛇Boiss。是葡萄牙特有的濒危物种。由于没有可用数据,对其植物化学成分和生物活性的研究将增加其使用和保护。LC-MS分析鼠尾草汤和氢乙醇提取物可鉴定出丹酚A异构体,胸腺中未对此进行描述属之前,迷迭香酸和丹酚酸K酸为主要酚类。木犀草素,芹菜素和雌黄醇含量较低。齐墩果酸和熊果酸仅存在于氢乙醇提取物中。煎剂提取了32.4%的通过彻底氢乙醇提取获得的酚类化合物。两种提取物均降低了三种癌细胞系(人乳腺癌:MCF-7,BT-474;鼠巨噬细胞:Raw 264.7)的活力,而氢乙醇提取物则显示出更高的活性。鼠尾草提取物具有显着的抗氧化剂,抗炎和抗增殖活性,并可能被建议作为天然抗氧化剂的新潜在来源及其作为新型功能食品的汤剂。

更新日期:2018-02-20
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