The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking,Metallomics

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The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking
Metallomics ( IF 2.9 ) Pub Date : 2018-02-21 00:00:00 , DOI: 10.1039/c8mt00015h
Daniel J. Kosman _{1,

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Affiliation

Eukaryotic cells, whether free-living or organismal, rely on metallo-reductases to process environmental ferric iron and cupric copper prior to uptake. In addition, some free-living eukaryotes (e.g. fungi and algae) couple ferri-reduction to ferro-oxidation, a process catalyzed by a small cohort of multi-copper oxidases; in these organisms, the ferric iron product is a ligand for cell iron uptake via a ferric iron permease. In addition to their support of iron uptake in lower eukaryotes, ferroxidases support ferrous iron efflux in Chordata; in this process the release of the ferrous iron from the efflux transporter is catalyzed by its ferroxidation. Last, ferroxidases also catalyze the oxidation of cuprous copper and, as metallo-oxidases, mirror the dual activity of the metallo-reductases. This Perspective examines the teleos of the yin–yang of this redox cycling of iron and copper in their metabolism.

中文翻译：

真核铁和铜运输中金属还原和金属氧化的目的

真核细胞，无论是自由生活的还是有机的，都依赖金属还原酶在摄取之前加工环境三价铁和铜铜。另外，一些自由生存的真核生物（例如真菌和藻类）将铁还原反应与铁氧化反应结合在一起，这是一小群多铜氧化酶催化的过程。在这些生物中，三价铁产物是通过细胞摄取铁的配体三价铁渗透酶。除支持低等真核生物吸收铁外，亚铁氧化酶还支持Chordata中的亚铁流出。在此过程中，亚铁从外排转运蛋白中的释放被铁的氧化作用催化。最后，亚铁氧化酶还催化铜亚铜的氧化，并且作为金属氧化酶，反映了金属还原酶的双重活性。本透视图考察了铁和铜在其新陈代谢中的氧化还原循环的阴阳之间的关系。

更新日期：2018-02-21

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