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Antibody‐Based Therapeutics: Ultrasensitive NIR‐SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-02-21 , DOI: 10.1002/adhm.201870019
Homan Kang 1 , Sinyoung Jeong 2 , Ahla Jo 3 , Hyejin Chang 2 , Jin-Kyoung Yang 4 , Cheolhwan Jeong 4 , San Kyeong 4 , Youn Woo Lee 3 , Animesh Samanta 5 , Kaustabh Kumar Maiti 5 , Myeong Geun Cha 2 , Taek-Keun Kim 6 , Sukmook Lee 6 , Bong-Hyun Jun 7 , Young-Tae Chang 8 , Junho Chung 9 , Ho-Young Lee 3 , Dae Hong Jeong 1, 2 , Yoon-Sik Lee 1, 4
Affiliation  

In article number 1700870, Yoon‐Sik Lee and co‐workers demonstrate in vivo validation process of candidate antibodies against human colon cancer, using a ratiometric quantification method. The validation is performed on a single mouse and analyzed by multiplexed surface‐enhanced resonance Raman scattering (SERRS) with ultrasensitive and near‐infrared (NIR)‐active SERRS nanoprobes (NIR‐SERRS dots).
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中文翻译:

基于抗体的治疗方法:具有多路定量定量的超灵敏NIR-SERRS探针,用于体内抗体引线验证(Adv。Healthcare Mater。4/2018)

Yoon-Sik Lee及其同事在文章1700870中使用比例定量方法论证了针对人类结肠癌的候选抗体的体内验证过程。验证在单只小鼠上进行,并通过具有超灵敏和近红外(NIR)活性的SERRS纳米探针(NIR-SERRS点)的多重表面增强共振拉曼散射(SERRS)进行分析。
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更新日期:2018-02-21
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