Two metal–organic frameworks (MOFs) containing bipyridinium moieties, UiO-67-MQ and UiO-67-DQ (MQ = N,N′-dimethyl-2,2′-bipyridinium, DQ = N,N′-ethylene 2,2′-bipyridinium), prepared by post-synthetic N-alkylation of the Zr-MOF with 2,2′-bipyridyl-4,4′-dicarboxylate (UiO-67-bpy, bpy = 2,2′-bipyridyl), were used as electrode modifiers for detection of dopamine. Compared with UiO-67-bpy, UiO-67-MQ and UiO-67-DQ significantly enhance the voltammetric sensitivity of dopamine, which is attributed to the donor–acceptor interactions between the electron-deficient bipyridinium moieties and the electron-rich analyte. The detection limits are further lowered by an order of magnitude by the introduction of multi-walled carbon nanotubes, demonstrating remarkable synergy in promoting electron-transfer kinetics. This work is the first report of the use of electron-deficient MOFs in electrochemical sensors.

两个包含联吡啶部分的金属有机骨架（MOF）UiO-67-MQ和UiO-67-DQ（MQ =  N，N'-二甲基-2,2'-联吡啶，DQ =  N，N'-乙烯2， 2'-联吡啶鎓），由合成后的NZr-MOF与2,2'-联吡啶-4,4'-二羧酸酯（UiO-67-bpy，bpy = 2,2'-联吡啶）的烷基化用作检测多巴胺的电极改性剂。与UiO-67-bpy相比，UiO-67-MQ和UiO-67-DQ显着提高了多巴胺的伏安敏感性，这归因于缺电子联吡啶鎓部分与富电子分析物之间的供体-受体相互作用。通过引入多壁碳纳米管，检测极限进一步降低了一个数量级，证明了在促进电子转移动力学方面的显着协同作用。这项工作是在电化学传感器中使用缺电子MOF的第一份报告。