A Capsule‐Type Microrobot with Pick‐and‐Drop Motion for Targeted Drug and Cell Delivery,Advanced Healthcare Materials

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A Capsule‐Type Microrobot with Pick‐and‐Drop Motion for Targeted Drug and Cell Delivery
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-02-20 , DOI: 10.1002/adhm.201700985
Seungmin Lee ₁ , Soyeun Kim ₂ , Sangwon Kim ₃ , Jin-Young Kim ₁ , Cheil Moon ₂ , Bradley J. Nelson _{1,

3} , Hongsoo Choi ₁

Affiliation

A capsule‐type microrobot exhibits “pick‐and‐drop” (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule‐type microrobot has two parts: a plunger and a cap. The fabricated microrobots are wirelessly controlled by a magnetic manipulator. Drugs or cells can be encapsulated in the container of the capsule‐type microrobot by the P&D motion or attached to the surface of the cap, which can be used as a supporting structure. Therefore, the capsule‐type microrobot can deliver suspended or adherent cells. The drug or cells are minimally exposed or not completely exposed to the surrounding fluid and do not experience shear force when encapsulated in the container. As a proof‐of‐concept, secure transportation of microparticles in the confined volume of the capsule via P&D motion is demonstrated. In addition, the cap is used as a scaffold for neuronal cell culture on a rat brain slice to demonstrate its biocompatibility and feasibility for targeted cell delivery. The proposed capsule‐type microrobot is suitable for diverse applications, as it protects the encapsulated materials.

中文翻译：

带有拖放动作的胶囊型微型机器人，用于靶向药物和细胞的输送

胶囊型微型机器人表现出“拾放”（P＆D）运动，以将颗粒保持在有限的体积内，并通过开瓶运动将其运输。P＆D运动之所以成为可能，是因为胶囊型微型机器人有两个部分：柱塞和盖子。所制造的微型机器人由电磁操纵器无线控制。药物或细胞可以通过P＆D运动封装在胶囊型微型机器人的容器中，也可以附着在帽盖的表面，用作支撑结构。因此，胶囊型微型机器人可以传递悬浮的或粘附的细胞。药物或细胞被最小限度地暴露或未完全暴露于周围流体，并且在封装在容器中时不会受到剪切力。作为概念证明，演示了通过P＆D运动确保微粒在胶囊密闭空间中的安全运输。另外，该帽用作大鼠脑切片上神经元细胞培养的支架，以证明其生物相容性和靶向细胞递送的可行性。拟议的胶囊型微型机器人适用于多种应用，因为它可以保护封装的材料。

更新日期：2018-02-20

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