The huge information storage capability of DNA and its ability to self‐assemble can be harnessed to enable massively parallel computing in a small space. DNA‐based logic gates are designed that rely on DNA strand displacement reactions; however, computation is slow due to time‐consuming DNA reassembly processes and prone to failure as DNA is susceptible to degradation by nucleases and under certain solution conditions. Here, it is shown that the presence of a cationic copolymer boosts the speed of DNA logic gate operations that involve multiple and parallel strand displacement reactions. Two kinds of DNA molecular operations, one based on a translator gate and one on a seesaw gate, are successfully enhanced by the copolymer without tuning of computing conditions or DNA sequences. The copolymer markedly reduces operation times from hours to minutes. Moreover, the copolymer enhances nuclease resistance.

中文翻译：

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阳离子共聚物助推DNA计算

DNA的巨大信息存储能力及其自组装能力可以在很小的空间内实现大规模并行计算。基于DNA的逻辑门的设计依赖于DNA链置换反应。但是，由于耗时的DNA重组过程，计算速度很慢，并且容易失败，因为DNA容易在一定的溶液条件下被核酸酶降解。在此，表明阳离子共聚物的存在提高了涉及多个和平行链置换反应的DNA逻辑门操作的速度。通过共聚物成功地增强了两种DNA分子操作，一种基于翻译器门，另一种基于跷跷板门，而无需调整计算条件或DNA序列。该共聚物将操作时间从数小时显着减少到数分钟。