One‐pot reactions of a lithiated (1H‐pyrrol‐1‐yl)allene, isothiocyanates, and alkyl 2‐bromoacetates or 2‐bromoacetonitrile were investigated. New classes of N–C‐linked pyrrole/thiophene ensembles bearing highly reactive substituents attached to the thiophene ring were synthesized. This new catalyst‐free strategy is scalable, and has been implemented on a gram scale.

中文翻译：

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氮杂三烯反应性的新面貌：5-氨基-3-甲基-4-（1H-吡咯-1-基）噻吩-2-羧酸盐和5-氨基-3-甲基-4-（1H吡咯）的捷径-1-基）噻吩-2-腈

研究了锂化的（1 H-吡咯-1-基）丙二烯，异硫氰酸酯和2-溴乙酸烷基酯或2-溴乙腈的单锅反应。合成了带有连接到噻吩环的高反应性取代基的新型Nc连接的吡咯/噻吩类化合物。这种新的无催化剂策略是可扩展的，并且已经以克为单位实施。