NiH‐Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)−H Alkylation of Alkenes,Angewandte Chemie International Edition

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NiH‐Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)−H Alkylation of Alkenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-03-13 , DOI: 10.1002/anie.201712731
Fang Zhou ₁ , Jin Zhu ₁ , Yao Zhang ₁ , Shaolin Zhu ₁

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The terminal‐selective, remote C(sp³)−H alkylation of alkenes was achieved by a relay process combining NiH‐catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp³)−C(sp³) bonds under mild conditions from two simple feedstock chemicals, namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large‐scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings.

中文翻译：

NiH催化的还原中继加氢烷基化：烯烃的远程C（sp3）-H烷基化的策略

烯烃的末端选择性远程C（sp ³）-H烷基化是通过结合NiH催化的加氢金属化，链行走和烷基化的中继过程实现的。该方法能够在温和条件下由两种简单的原料化学品即烯烃和烷基卤化物构造未官能化的C（sp ³）-C（sp ³）键。在低催化剂负载下，烯烃异构混合物的大规模和区域会聚烷基化进一步证明了这种转化的实用价值。

更新日期：2018-03-13

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