CRISPRs from scratch

CRISPRs from scratch, Published online: 20 February 2018; doi:10.1038/s41564-018-0115-9

CRISPR immunity begins with the acquisition of sequences from invading nucleic acids through spacer integration into a CRISPR locus. Off-target integration of spacers into other parts of the genome is now implicated as a spontaneous source of new CRISPR loci.

中文翻译：

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从零开始的CRISPR

从零开始的CRISPR

CRISPR从头开始，在线发布：2018年2月20日; doi：10.1038 / s41564-018-0115-9

CRISPR免疫始于通过间隔子整合入CRISPR基因座来从入侵核酸中获取序列。间隔子脱靶整合到基因组的其他部分现在被认为是新CRISPR基因座的自发来源。