Immunotherapy: Cancer immunotherapy and the value of cure

Immunotherapy: Cancer immunotherapy and the value of cure, Published online: 20 February 2018; doi:10.1038/nrclinonc.2018.27

Patients value anticancer therapies that provide durable clinical responses; immune-checkpoint inhibitors can provide such benefit for patients with some advanced-stage malignancies, albeit only for a minority of those treated. Modern oncology value frameworks have set efficacy thresholds in an attempt to assess the clinical benefit of anticancer therapeutics. But, is the benefit of durable cancer control reflected in these thresholds?

中文翻译：

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免疫疗法：癌症免疫疗法和治愈的价值

免疫疗法：癌症免疫疗法和治愈的价值

免疫疗法：癌症免疫疗法和治愈的价值，在线发布：2018 年 2 月 20 日；doi:10.1038/nrclinonc.2018.27

患者重视提供持久临床反应的抗癌疗法；免疫检查点抑制剂可以为患有某些晚期恶性肿瘤的患者提供这种益处，尽管仅对少数接受治疗的患者有益。现代肿瘤学价值框架已经设定了疗效阈值，以试图评估抗癌疗法的临床益处。但是，这些阈值是否反映了持久控制癌症的好处？