NF00659B₁ is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B₁ is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B₁ for further biological studies.

中文翻译：

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NF00659B ₁立体选择性合成的合成努力

NF00659B ₁是具有有效的抗结肠癌活性的新型α-吡喃酮二萜类天然产物。描述了对NF00659B ₁的2,2-二甲基氧戊醇核的立体选择性方法，其中列出了一系列烯属酯环闭合复分解，环氧化和格氏试剂的添加。该策略为全合成NF00659B ₁进行进一步的生物学研究铺平了道路。