The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R²) and the left aryl group (R³) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats.

中文翻译：

---

新型7-氮杂螺[3.5]壬烷衍生物作为GPR119激动剂的设计，合成及生物学评价

描述了新型7-氮杂螺[3.5]壬烷GPR119激动剂的设计和合成。在该系列中，右哌啶N封端基团（R ²）和左芳基基团（R ³）的优化导致将化合物54g鉴定为有效的GPR119激动剂。化合物54g在Sprague-Dawley（SD）大鼠中显示出理想的PK分布，在糖尿病大鼠中表现出良好的降糖效果。