Protein-Mediated Shape Control of Silver Nanoparticles,Bioconjugate Chemistry

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Protein-Mediated Shape Control of Silver Nanoparticles
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-02-20 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00034
Indranath Chakraborty _{1,

2} , Neus Feliu _{2,

3} , Sathi Roy _{1,

2} , Kenneth Dawson ₄ , Wolfgang J. Parak _{1,

2,

5}

Affiliation

Silver nanoparticles were grown in aqueous solution, without the presence of typical surfactant molecules, but under the presence of different proteins. The shape of the resulting silver nanoparticles could be tuned by the selection of the types of proteins. The amount of accessible lysine groups was found to be mainly responsible for the anisotropy in nanoparticle formation. Viability measurements of cells exposed to protein capped spherical or prism-shaped NPs did not reveal differences between both geometries. Thus, in the case of protein-only coated Ag NPs, no shape-induced toxicity was found under the investigated exposure conditions.

中文翻译：

蛋白质介导的银纳米粒子的形状控制

银纳米颗粒在水溶液中生长，不存在典型的表面活性剂分子，但存在不同的蛋白质。可以通过选择蛋白质类型来调节所得银纳米颗粒的形状。发现可接近的赖氨酸基团的数量主要负责纳米颗粒形成中的各向异性。暴露于蛋白质加盖的球形或棱柱形NP的细胞的活力测量未揭示两种几何结构之间的差异。因此，在仅蛋白质包被的银纳米颗粒的情况下，在研究的暴露条件下未发现形状诱导的毒性。

更新日期：2018-02-20

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