Recently, theranostic has drawn tremendous attention by virtue of the nanotechnology development and new material exploration. Herein, we reported a novel theranostic system by loading Au nanoclusters (AuNCs) and Chlorin e6 (photosensitizer, Ce6) onto the monolayer nanosheet surface of Gd-doped layered double hydroxide (Gd-LDH). The as-prepared Ce6&AuNCs/Gd-LDH exhibits a largely enhanced fluorescence quantum yield (QY) of 18.5% relative to pristine AuNCs (QY = 3.1%) as well as superior T₁ magnetic resonance imaging (MRI) performance (r₁ = 17.57 mM⁻¹s⁻¹) compared with commercial MRI contrast agent (Gd(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd-DOTA): r₁ ˜ 3.4 mM⁻¹s⁻¹), resulting from a synergistic effect between AuNCs and Gd-LDH. In addition, both in vitro and in vivo therapeutic evaluations demonstrate an efficient dual-modality imaging guided anticancer performance, especially the synergetic enhanced magnetic resonance/fluorescence (MR/FL) visualization of tumor site. Therefore, this work demonstrates a successful paradigm for the design and preparation of LDHs monolayer-based theranostic material, which holds great promises in practical applications.

近来，随着纳米技术的发展和新材料的探索，岩石学引起了极大的关注。在这里，我们通过将金纳米团簇（AuNCs）和氯绿素e6（光敏剂，Ce6）加载到掺Gd的层状双氢氧化物（Gd-LDH）的单层纳米片表面上，报道了一种新型的诊断学系统。相对于原始的AuNCs（QY = 3.1％），制备的Ce6＆AuNCs / Gd-LDH的荧光量子产率（QY）大大提高了18.5％，并且具有出色的T ₁磁共振成像（MRI）性能（r ₁  = 17.57 mM ^-1 s ^-1）与市售MRI造影剂（Gd（III）-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（Gd-DOTA））比较：r ₁〜3.4  mM ^-1 s ^-1），这是由于AuNC与Gd-LDH之间的协同作用所致。另外，体外和体内治疗评估均显示了有效的双峰成像引导的抗癌性能，尤其是肿瘤部位的协同增强的磁共振/荧光（MR / FL）可视化。因此，这项工作证明了基于LDHs单层的治疗药物的设计和制备成功的范例，在实际应用中具有广阔的前景。