Anthropogenic compounds accidentally released to the environment could be important precursors of disinfection byproducts (DBPs) in drinking water treatment processes. In this study, the haloacetic acid formation potentials (HAAFPs) of 155 anthropogenic compounds listed on the Japanese pollutant release and transfer register (PRTR) system were evaluated. The results showed that phenolic and aromatic amine compounds were important HAA precursors, and chlorinated phenols showed high HAAFPs (>400 μg/mgC). Moreover, trichlorfon and ethyl chloroacetate (HAAFP of 104.9 and 602.3 μg/mgC, respectively) were also important HAA precursors because of their ability to undergo hydrolysis. Although most anthropogenic compounds with high HAAFPs showed high chlorine consumptions, no clear correlation between HAAFPs and chlorine consumptions was found in this study. In addition, the quantitative structure-activity relationship (QSAR) approach was a useful tool for predicting the chlorine consumption of organic compounds but was not effective for predicting HAAFPs based on the information currently available. A scenario study assuming a hypothetical accidental release predicted that the release of 3,4-dichloroaniline (HAAFP of 407.6 μg/mgC) would lead to a violation of the current drinking water quality standards for HAAs in Japan.

意外释放到环境中的人为化合物可能是饮用水处理过程中消毒副产物（DBP）的重要前体。在这项研究中，评估了日本污染物释放和转移登记（PRTR）系统中列出的155种人为化合物的卤乙酸形成潜力（HAAFP）。结果表明，酚胺和芳族胺化合物是重要的HAA前体，而氯化酚显示出高HAAFP（> 400μg/ mgC）。此外，敌百虫和氯乙酸乙酯（分别为104.9和602.3μg/ mgC的HAAFP）也是重要的HAA前体，因为它们具有水解能力。尽管大多数具有高HAAFP的人为化合物都显示出较高的氯消耗量，在这项研究中，没有发现HAAFP和氯气消耗之间存在明显的相关性。此外，定量构效关系（QSAR）方法是预测有机化合物氯消耗的有用工具，但根据当前可用信息无法有效预测HAAFP。假设假性事故释放的情景研究预测，3,4-二氯苯胺的释放（HAAFP为407.6μg/ mgC）将导致违反日本现行的HAA饮用水水质标准。