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Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics
ACS Nano ( IF 15.8 ) Pub Date : 2018-02-20 00:00:00 , DOI: 10.1021/acsnano.7b07252 Emily B Ehlerding 1 , Piotr Grodzinski 1 , Weibo Cai , Christina H Liu 1
ACS Nano ( IF 15.8 ) Pub Date : 2018-02-20 00:00:00 , DOI: 10.1021/acsnano.7b07252 Emily B Ehlerding 1 , Piotr Grodzinski 1 , Weibo Cai , Christina H Liu 1
Affiliation
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The importance of medical imaging in the diagnosis and monitoring of cancer cannot be overstated. As personalized cancer treatments are gaining popularity, a need for more advanced imaging techniques has grown significantly. Nanoparticles are uniquely suited to fill this void, not only as imaging contrast agents but also as companion diagnostics. This review provides an overview of many ways nanoparticle imaging agents have contributed to cancer imaging, both preclinically and in the clinic, as well as charting future directions in companion diagnostics. We conclude that, while nanoparticle-based imaging agents are not without considerable scientific and developmental challenges, they enable enhanced imaging in nearly every modality, hold potential as in vivo companion diagnostics, and offer precise cancer treatment and maximize intervention efficacy.
中文翻译：
小药剂的巨大潜力：用于基于成像的伴随诊断的纳米颗粒
医学成像在癌症诊断和监测中的重要性怎么强调也不为过。随着个性化癌症治疗越来越受欢迎，对更先进的成像技术的需求显着增长。纳米颗粒非常适合填补这一空白，不仅可以作为成像造影剂，还可以作为伴随诊断。这篇综述概述了纳米颗粒成像剂在临床前和临床中对癌症成像做出贡献的多种方式，并描绘了伴随诊断的未来方向。我们的结论是，虽然基于纳米颗粒的成像剂并非没有相当大的科学和开发挑战，但它们能够增强几乎所有模式的成像，具有体内伴随诊断的潜力，并提供精确的癌症治疗和最大限度地提高干预效果。
更新日期：2018-02-20
中文翻译：
小药剂的巨大潜力：用于基于成像的伴随诊断的纳米颗粒
医学成像在癌症诊断和监测中的重要性怎么强调也不为过。随着个性化癌症治疗越来越受欢迎，对更先进的成像技术的需求显着增长。纳米颗粒非常适合填补这一空白，不仅可以作为成像造影剂，还可以作为伴随诊断。这篇综述概述了纳米颗粒成像剂在临床前和临床中对癌症成像做出贡献的多种方式，并描绘了伴随诊断的未来方向。我们的结论是，虽然基于纳米颗粒的成像剂并非没有相当大的科学和开发挑战，但它们能够增强几乎所有模式的成像，具有体内伴随诊断的潜力，并提供精确的癌症治疗和最大限度地提高干预效果。
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