Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures†,Soft Matter

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Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures†
Soft Matter ( IF 2.9 ) Pub Date : 2018-02-19 00:00:00 , DOI: 10.1039/c7sm02188g
Naohito Urakami _{1,

2,

3,

4} , Takehiro Jimbo _{4,

5,

6,

7} , Yuka Sakuma _{4,

5,

6,

7} , Masayuki Imai _{4,

5,

6,

7}

Affiliation

We investigated the effects of lipid geometry on vesicle division using coarse grained molecular dynamics simulations. When the vesicle is composed of zero and negative spontaneous curvature lipids (ZSLs and NSLs), the difference in their molecular spontaneous curvatures destabilizes the neck of the limiting shape vesicle. In the vesicle division pathway, the neck developed into the stalk intermediates. The stalk was broken when the NSLs were expelled from the stalk. Free energy analysis shows that the coupling between the lipid geometry and the Gaussian rigidity is responsible for the observed vesicle division.

中文翻译：

脂质几何结构和膜曲率之间的耦合引起的囊泡分裂的分子机制†

我们使用粗粒分子动力学模拟研究脂质几何形状对囊泡分裂的影响。当囊泡由零和负的自发曲率脂质（ZSLs和NSLs）组成时，它们分子自发曲率的差异会使局限型囊泡的颈部不稳定。在囊泡分裂途径中，颈部发育成茎的中间体。NSL被从秸秆中驱除时，秸秆被折断了。自由能分析表明，脂质几何结构和高斯刚度之间的耦合是观察到的囊泡分裂的原因。

更新日期：2018-02-19

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