A catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols has been established in the presence of chiral phosphoric acids, which constructed chiral cyclopenta[b]indole frameworks in generally good yields (up to 90%), high diastereoselectivities (up to >95 : 5 dr) and excellent enantioselectivities (up to 96% ee). This reaction not only provides an easy access to chiral cyclopenta[b]indole scaffolds, but also advances the chemistry of indolylmethanols, especially catalytic asymmetric transformations of indolylmethanols.

中文翻译：

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通过2-萘酚与2-吲哚甲醇的催化不对称串联环化反应， 构筑手性环戊[ b ]吲哚骨架的非对映和对映选择性†

2- indolymethanols与2-萘酚的催化非对称串联环化已建立的手性磷酸的存在下，其构成手性环戊二烯并[ b ]在通常良好的产率的吲哚骨架（高达90％），高非对映选择性（高达> 95：5 dr）和出色的对映选择性（高达96％ee）。该反应不仅提供了容易获得手性环戊[ b ]吲哚骨架的方法，而且还提高了吲哚基甲醇的化学反应，特别是吲哚基甲醇的催化不对称转化。