Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica,Chemical Communications

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Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica
Chemical Communications ( IF 4.3 ) Pub Date : 2018-02-19 00:00:00 , DOI: 10.1039/c7cc09402g
Kerda Keevend _{1,

2,

3} , Guido Panzarasa _{2,

3,

4} , Fabian H. L. Starsich _{3,

5,

6} , Martin Zeltner _{3,

7,

8} , Anastasia Spyrogianni _{3,

5,

6,

9,

10} , Elena Tsolaki _{11,

12,

13} , Giuseppino Fortunato _{2,

3,

4} , Sotiris E. Pratsinis _{3,

5,

6} , Sergio Bertazzo _{11,

12,

13} , Inge K. Herrmann _{1,

2,

3}

Affiliation

Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa)
St. Gallen
Switzerland
Biomimetic Membranes and Textiles, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa)
Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich
CH-8092 Zurich
Functional Materials Laboratory, Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich
CH-8093 Zurich
Currently at Institute of Pharmaceutical Sciences
ETH Zurich
Departments of Medical Physics and Biomedical Engineering, University College London (UCL), Malet Place Engineering Building
London
UK

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.

中文翻译：

火焰发光的掺有Tb ^3+的氧化钇颗粒的熔融法聚乙二醇化：血液相容性，细胞吸收以及与二氧化硅的比较

火焰气溶胶技术是一种可扩展的纳米颗粒合成方法。由于颗粒是在干燥状态下产生和收集的，因此分散性和进一步的功能化可能会阻碍其生物医学应用。我们报告了一锅，可扩展和鲁棒的程序的火焰化氧化钇和二氧化硅纳米粒子的聚乙二醇化。我们证明了改善的胶体稳定性，减弱了凝血的活化作用并减少了对吞噬细胞的摄取，所有这些均为火焰状氧化物纳米粒子的生物医学应用铺平了道路。

更新日期：2018-03-15

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