Purpose

To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED).

Design

Cross-sectional observational study.

Participants

This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21–90 years]) for analysis.

Methods

Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated.

Main Outcome Measures

Schirmer value, tear film breakup time (TBUT), and keratoconjunctival score.

Results

We classified the participants into aqueous-deficient dry eye (ADDE; n = 231 [51.4%]) and short TBUT dry eye subtype (TBUT-DE; n = 109 [24.3%]) subgroups. The TBUT was shorter in patients with MGD than in those without MGD, whereas other ocular signs showed no difference (TBUT: MGD present, 1.97±1.02 seconds; MGD absent, 2.94±1.63 seconds [P < 0.001]; ADDE/MGD present, 1.94±1.08 seconds; ADDE/MGD absent, 2.77±1.61 seconds [P < 0.001]; short TBUT-DE/MGD present, 2.07±0.97 seconds; short TBUT-DE/MGD absent, 2.94±1.23 seconds [P = 0.01]). The ADDE patients with FRD showed a worse TBUT than ADDE patients without FRD (TBUT: ADDE/FRD present, 2.08±1.39 seconds; ADDE/FRD absent, 2.92±1.54 seconds; P < 0.001).

Conclusions

This study showed associations between MGD, FRD, or both and ocular signs in DED. In the presence of MGD, FRD, or both, TBUT was significantly shortened regardless of the dry eye status or subtype.

中文翻译：

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睑板腺功能障碍和与摩擦有关的疾病对干眼症严重程度的影响

目的

评估睑板腺功能障碍（MGD）和摩擦相关疾病（FRD）对干眼症（DED）严重程度的影响。

设计

横断面观察研究。

参加者

这项研究招募了449例DED患者（男63例，女386例；平均年龄62.6±15.7岁[范围21-90岁]）。

方法

研究了主观症状，眼表，泪液功能以及MGD和FRD（上缘角膜结膜炎，结膜软化和睑板擦拭上皮病）的存在。

主要观察指标

Schirmer值，泪膜破裂时间（TBUT）和角膜结膜评分。

结果

我们将参与者分为水缺乏型干眼（ADDE； n = 231 [51.4％]）和短TBUT干眼亚型（TBUT-DE； n = 109 [24.3％]）亚组。MGD患者的TBUT短于无MGD患者的TBUT，而其他眼部症状无差异（TBUT：存在MGD，1.97±1.02秒；不存在MGD，2.94±1.63秒[ P <0.001]；存在ADDE / MGD， 1.94±1.08秒；不存在ADDE / MGD，2.77±1.61秒[ P <0.001]；存在短TBUT-DE / MGD，2.07±0.97秒；不存在TBUT-DE / MGD短，2.94±1.23秒[ P  = 0.01] ）。患有FRD的ADDE患者的TBUT较未患有FRD的ADDE患者差（TBUT：存在ADDE / FRD，2.08±1.39秒；不存在ADDE / FRD，2.92±1.54秒；P  <0.001）。

结论

这项研究显示了MGD，FRD或两者与DED的眼部症状之间的关联。在存在MGD，FRD或两者同时存在的情况下，无论干眼状态或亚型如何，TBUT都会显着缩短。