Front Cover: Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein‐Detected NMR Spectroscopy (ChemBioChem 5/2018),ChemBioChem

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Front Cover: Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein‐Detected NMR Spectroscopy (ChemBioChem 5/2018)
ChemBioChem ( IF 2.6 ) Pub Date : 2018-02-16 , DOI: 10.1002/cbic.201800074
John M. Egner ₁ , Davin R. Jensen ₁ , Michael D. Olp ₁ , Nolan W. Kennedy ₁ , Brian F. Volkman ₁ , Francis C. Peterson ₁ , Brian C. Smith ₁ , R. Blake Hill ₁

Affiliation

The front cover picture shows chemical fragment‐based screening by a 2D protein‐detected nuclear magnetic resonance approach. A novel scoring metric, difference intensity analysis (gray, yellow, and blue bar plot), was developed to quantitate NMR spectral changes and discriminate between compounds according to whether they gave rise to hits, non‐hits, or nonspecific NMR crosspeak broadening due to aggregation. More information can be found in the full paper by R. B. Hill et al. on page 448 in Issue 5, 2018 (DOI: 10.1002/cbic.201700386).

中文翻译：

封面：通过蛋白质检测NMR光谱筛查化学文库的2D差异强度分析的开发和验证（ChemBioChem 5/2018）

封面图片显示了通过2D蛋白检测的核磁共振方法进行的基于化学片段的筛选。开发了一种新颖的评分指标，差异强度分析（灰色，黄色和蓝色条形图），以定量NMR光谱变化并根据化合物是由于引起峰，非峰还是非特异性NMR交叉峰展宽而区分化合物聚合。可以在R. B. Hill等人的全文中找到更多信息。就在第5期，2018页448（：10.1002 / cbic.201700386 DOI）。

更新日期：2018-02-16

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