People obtain pectins from plant foods. It has been shown that pectins change the concentration of cytokines. Numerous studies have demonstrated the influence of the immune system on the brain. Thus, we examined the effects of pectins on recognition memory, depression-like behaviour, spontaneous activity, the TNF-α, IL-1β, IL-6, and IFN-γ concentrations, and the NF-κB, STAT3 and pSTAT3 protein levels in mouse hippocampi. Mice treated with pectins showed better recognition memory and an antidepressant-like effect. Pectins did not affect the spontaneous behaviour of the mice. Pectins increased the concentrations of IL-6 and IFN-γ in mouse hippocampi, and they decreased STAT3 and increased pSTAT3 protein levels. Our data demonstrate that pectins produce an improvement in memory and an antidepressant-like behaviour compared to control mice, and these effects may be at least partially due to their influence on the concentration of IL-6 and the activation of the JAK-STAT signalling pathway in mouse hippocampi.

人们从植物性食品中获取果胶。已经显示果胶改变细胞因子的浓度。大量研究证明了免疫系统对大脑的影响。因此，我们研究了果胶对识别记忆，抑郁样行为，自发活动，TNF-α，IL-1β，IL-6和IFN-γ浓度以及NF-κB，STAT3和pSTAT3蛋白水平的影响。在小鼠海马体中。用果胶处理的小鼠表现出更好的识别记忆和抗抑郁样作用。果胶不影响小鼠的自发行为。果胶增加小鼠海马中IL-6和IFN-γ的浓度，并降低STAT3和增加pSTAT3蛋白水平。我们的数据表明，与对照小鼠相比，果胶可改善记忆力，并具有抗抑郁样行为，