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Enabling Angioplasty‐Ready “Smart” Stents to Detect In‐Stent Restenosis and Occlusion
Advanced Science ( IF 14.3 ) Pub Date : 2018-02-16 , DOI: 10.1002/advs.201700560 Xing Chen 1, 2 , Babak Assadsangabi 1 , York Hsiang 3 , Kenichi Takahata 1
Advanced Science ( IF 14.3 ) Pub Date : 2018-02-16 , DOI: 10.1002/advs.201700560 Xing Chen 1, 2 , Babak Assadsangabi 1 , York Hsiang 3 , Kenichi Takahata 1
Affiliation
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Despite the multitude of stents implanted annually worldwide, the most common complication called in‐stent restenosis still poses a significant risk to patients. Here, a “smart” stent equipped with microscale sensors and wireless interface is developed to enable continuous monitoring of restenosis through the implanted stent. This electrically active stent functions as a radiofrequency wireless pressure transducer to track local hemodynamic changes upon a renarrowing condition. The smart stent is devised and constructed to fulfill both engineering and clinical requirements while proving its compatibility with the standard angioplasty procedure. Prototypes pass testing through assembly on balloon catheters withstanding crimping forces of >100 N and balloon expansion pressure up to 16 atm, and show wireless sensing with a resolution of 12.4 mmHg. In a swine model, this device demonstrates wireless detection of blood clot formation, as well as real‐time tracking of local blood pressure change over a range of 108 mmHg that well covers the range involved in human. The demonstrated results are expected to greatly advance smart stent technology toward its clinical practice.
中文翻译：
使血管成形术就绪的“智能”支架能够检测支架内再狭窄和闭塞
尽管全世界每年植入大量支架，但最常见的并发症——支架内再狭窄仍然对患者构成重大风险。这里，开发了一种配备微型传感器和无线接口的“智能”支架，可以通过植入的支架持续监测再狭窄。这种电活性支架充当射频无线压力传感器，以跟踪再狭窄情况下的局部血流动力学变化。智能支架的设计和制造是为了满足工程和临床要求，同时证明其与标准血管成形术程序的兼容性。原型通过球囊导管上的组装测试，可承受 >100 N 的压接力和高达 16 atm 的球囊膨胀压力，并显示分辨率为 12.4 mmHg 的无线传感。在猪模型中，该设备展示了对血凝块形成的无线检测，以及在 108 mmHg 范围内实时跟踪局部血压变化，这很好地覆盖了人类的范围。所展示的结果预计将极大地推动智能支架技术走向临床实践。
更新日期：2018-02-16
中文翻译：
使血管成形术就绪的“智能”支架能够检测支架内再狭窄和闭塞
尽管全世界每年植入大量支架，但最常见的并发症——支架内再狭窄仍然对患者构成重大风险。这里，开发了一种配备微型传感器和无线接口的“智能”支架，可以通过植入的支架持续监测再狭窄。这种电活性支架充当射频无线压力传感器，以跟踪再狭窄情况下的局部血流动力学变化。智能支架的设计和制造是为了满足工程和临床要求，同时证明其与标准血管成形术程序的兼容性。原型通过球囊导管上的组装测试，可承受 >100 N 的压接力和高达 16 atm 的球囊膨胀压力，并显示分辨率为 12.4 mmHg 的无线传感。在猪模型中，该设备展示了对血凝块形成的无线检测，以及在 108 mmHg 范围内实时跟踪局部血压变化，这很好地覆盖了人类的范围。所展示的结果预计将极大地推动智能支架技术走向临床实践。
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