Tropoelastin Implants That Accelerate Wound Repair,Advanced Healthcare Materials

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Tropoelastin Implants That Accelerate Wound Repair
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-02-16 , DOI: 10.1002/adhm.201701206
Suzanne M Mithieux _{1,

2} , Behnaz Aghaei-Ghareh-Bolagh _{1,

2} , Leping Yan _{1,

2} , Kekini V Kuppan _{1,

2,

3} , Yiwei Wang ₄ , Francia Garces-Suarez ₄ , Zhe Li ₄ , Peter K Maitz ₄ , Elizabeth A Carter ₅ , Christina Limantoro _{6,

7} , Wojciech Chrzanowski _{6,

7} , David Cookson ₈ , Alan Riboldi-Tunnicliffe ₈ , Clair Baldock ₉ , Kosuke Ohgo ₁₀ , Kristin K Kumashiro ₁₀ , Glenn Edwards ₁₁ , Anthony S Weiss _{1,

2,

12}

Affiliation

School of Life and Environmental Sciences, University of Sydney, NSW, 2006, Australia.
Charles Perkins Centre, University of Sydney, NSW, 2006, Australia.
Heart Research Institute, University of Sydney, NSW, 2006, Australia.
Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW, 2139, Australia.
Vibrational Spectroscopy Core Facility and Faculty of Chemistry, University of Sydney, NSW, 2006, Australia.
Faculty of Pharmacy, University of Sydney, NSW, 2006, Australia.
Australian Institute for Nanoscale Science and Technology, University of Sydney, NSW, 2006, Australia.
Australian Synchrotron ANSTO, VIC, 3168, Australia.
Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, UK.
Department of Chemistry, University of Hawaii, Honolulu, HI, 96822, USA.
School of Animal and Veterinary Sciences, Charles Sturt University, NSW, 2678, Australia.
Bosch Institute, University of Sydney, NSW, 2006, Australia.

A novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat‐based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co‐treatment with full‐ and split‐thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point‐of‐care treatment of open wounds is provided.

中文翻译：

加速伤口修复的原弹性蛋白植入物

提出了一种新型的纯合成材料，可促进全层皮肤伤口的修复。活性成分是原弹性蛋白，并利用其促进新血管形成的能力及其细胞募集特性来加速伤口修复。该技术的关键是使用一种新的基于热的稳定形式的人体原弹性蛋白，它允许可调节的吸收。这种可植入材料提供了一个定制的插入物，可以塑造成伤口床的形状，在那里它水合形成一种适形的蛋白质水凝胶。证明了在健康猪的伤口愈合、皮肤修复和成熟上皮再生方面的显着益处。该植入物与全层和分层皮肤移植物的初始联合治疗兼容。植入物优于无菌包扎，显示了商业水凝胶和真皮再生模板产品。在此基础上，提出了一种用于即时治疗开放性伤口的预制组织修复材料的新概念。

更新日期：2018-02-16

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