ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation†,Chemical Science

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ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation†
Chemical Science ( IF 7.6 ) Pub Date : 2018-02-16 00:00:00 , DOI: 10.1039/c7sc05476a
Jia Yao ₁ , Yuan Cheng ₁ , Min Zhou ₁ , Sheng Zhao ₁ , Shichao Lin ₁ , Xiaoyu Wang ₁ , Jiangjiexing Wu ₁ , Sirong Li ₁ , Hui Wei _{1,

2}

Affiliation

Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases, including cardiovascular disease and cancer. Though highly efficient natural ROS scavenging enzymes have been evolved, they are sensitive to environmental conditions and hard to mass-produce. Therefore, enormous efforts have been devoted to developing artificial enzymes with ROS scavenging activities. Among them, ROS scavenging nanozymes have recently attracted great interest owing to their enhanced stability, multi-functionality, and tunable activity. It has been implicated that Mn-contained nanozymes would possess efficient ROS scavenging activities, however only a few such nanozymes have been reported. To fill this gap, herein we demonstrated that Mn₃O₄ nanoparticles (NPs) possessed multiple enzyme mimicking activities (i.e., superoxide dismutase and catalase mimicking activities as well as hydroxyl radical scavenging activity). The Mn₃O₄ nanozymes therefore significantly scavenged superoxide radical as well as hydrogen peroxide and hydroxyl radical. Moreover, they were not only more stable than the corresponding natural enzymes but also superior to CeO₂ nanozymes in terms of ROS elimination. We showed that the Mn₃O₄ NPs not only exhibited excellent ROS removal efficacy in vitro but also effectively protected live mice from ROS-induced ear-inflammation in vivo. These results indicated that Mn₃O₄ nanozymes are promising therapeutic nanomedicine for treating ROS-related diseases.

中文翻译：

ROS 清除 Mn3O4 纳米酶用于体内抗炎†

活性氧（ROS）诱导的氧化应激与多种疾病有关，包括心血管疾病和癌症。尽管高效的天然ROS清除酶已经被开发出来，但它们对环境条件敏感且难以大规模生产。因此，人们致力于开发具有ROS清除活性的人工酶。其中，ROS清除纳米酶由于其增强的稳定性、多功能性和可调节的活性而最近引起了人们的极大兴趣。有人认为含锰纳米酶具有有效的 ROS 清除活性，但目前只有少数此类纳米酶被报道。为了填补这一空白，本文中我们证明Mn ₃ O ₄纳米颗粒(NP)具有多种酶模拟活性(即，超氧化物歧化酶和过氧化氢酶模拟活性以及羟自由基清除活性)。因此，Mn ₃ O ₄纳米酶显着清除超氧自由基以及过氧化氢和羟基自由基。此外，它们不仅比相应的天然酶更稳定，而且在ROS消除方面优于CeO ₂纳米酶。我们表明，Mn ₃ O ₄ NPs不仅在体外表现出优异的ROS去除功效，而且在体内有效保护活小鼠免受ROS诱导的耳部炎症。这些结果表明Mn ₃ O ₄纳米酶是治疗ROS相关疾病的有前途的治疗性纳米药物。

更新日期：2018-02-16

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