Smart self-assembled microgel films as encapsulating carriers for UV-absorbing molecules†,Polymer Chemistry

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Smart self-assembled microgel films as encapsulating carriers for UV-absorbing molecules†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-02-16 00:00:00 , DOI: 10.1039/c8py00146d
Garbiñe Aguirre _{1,

2,

3,

4,

5} , Abdel Khoukh _{1,

2,

3,

4,

5} , Pablo Taboada _{6,

7,

8,

9,

10} , Kamel Chougrani _{11,

12,

13} , Valérie Alard _{11,

12,

13} , Laurent Billon _{1,

2,

3,

4,

5}

Affiliation

This article reports the ability of oligo(ethylene glycol)-based stimuli-responsive microgels to spontaneously form self-assembled microgel films under different conditions such as the presence or absence of water soluble polymers (WSP, formed during the microgel synthesis) and the type and/or amount of salt in the microgel dispersion. The unusually high encapsulation of four different cosmetically active molecules has been achieved via hydrophobic interactions and hydrogen-bonding interactions between the –OH groups of active molecules and ether functions of self-assembled microgel films. The loaded-films present absorption higher than 50% of the UVA–UVB wavelengths and can be used for skin protection against sun. The nature of the interactions was determined by NOESY-NMR spectroscopy in the gel state. Moreover, confocal microscopy was used to show that the water solubility of the active molecule plays a crucial role in obtaining a more homogeneous distribution in films after loading.

中文翻译：

智能自组装微凝胶膜作为吸收紫外线的分子的封装载体†

本文报道了基于低聚（乙二醇）的刺激响应性微凝胶在不同条件下自发形成自组装微凝胶膜的能力，例如存在或不存在水溶性聚合物（在微凝胶合成过程中形成的WSP）和类型和/或微凝胶分散液中盐的量。四个不同的化妆品活性分子的异常高封装率已经通过活性分子的–OH基团与自组装微凝胶膜的醚功能之间存在疏水相互作用和氢键相互作用。负载膜的吸收率高于UVA–UVB波长的50％，可用于皮肤防晒。相互作用的性质通过凝胶状态下的NOESY-NMR光谱确定。此外，共聚焦显微镜用于显示活性分子的水溶性在加载后在薄膜中获得更均匀的分布中起着至关重要的作用。

更新日期：2018-02-16

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