Metallome evolution in ageing C. elegans and a copper stable isotope perspective†,Metallomics

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Metallome evolution in ageing C. elegans and a copper stable isotope perspective†
Metallomics ( IF 2.9 ) Pub Date : 2018-02-15 00:00:00 , DOI: 10.1039/c7mt00318h
Lucie Sauzéat _{1,

2,

3,

4,

5} , Anne Laurençon _{3,

5,

6,

7,

8} , Vincent Balter _{1,

2,

3,

4,

5}

Affiliation

Ageing is accompanied by important chemical deregulations resulting in bodily metal imbalances. The way and extent to which these deregulations are associated with ageing processes are however poorly understood and their use as potential biomarkers of ageing has not been investigated. In this study, we report whole-body elementary concentrations and copper and zinc isotopic compositions of Caenorhabditis elegans in ageing wild type (i.e. ‘normal’-lived) and mutant (i.e. short and long-lived) strains. We show that the strains are characterized by different levels of mutation-related variations such as in phosphorus and magnesium as well as in zinc isotopic composition. During ageing, strains are affected by elemental age-related variations, such as an increase in calcium and iron concentrations and a decrease in the copper isotopic composition and concentration for long-lived mutants. The deregulated metabolism of copper seems to be connected to ageing probably in association with the production of reactive oxygen species. We emphasize that the copper stable isotope composition could serve as a biomarker of normal or accelerated ageing in the future.

中文翻译：

老化线虫和铜稳定同位素的金属分子演化†

老化伴随着重要的化学失调，导致身体金属失衡。然而，人们对这些放松管制与衰老过程相关的方式和程度了解甚少，还没有研究它们作为衰老的潜在生物标志物的用途。在这项研究中，我们报道了全身的基本浓度和铜和锌的同位素组成秀丽隐杆线虫衰老野生型（即“normal'寿命）和突变体（即短寿命和长寿命）菌株。我们表明该菌株的特征在于不同水平的突变相关变异，例如磷和镁以及锌同位素组成。在老化过程中，菌株会受到与年龄相关的基本变化的影响，例如钙和铁的浓度增加以及长寿命突变体的铜同位素组成和浓度降低。铜代谢失控似乎与衰老有关，可能与活性氧的产生有关。我们强调，稳定的铜同位素组成可能会在将来成为正常或加速老化的生物标记。

更新日期：2018-02-15

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