Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application,Chemical Society Reviews

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Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-02-15 00:00:00 , DOI: 10.1039/c7cs00573c
Hong Zhou _{1,

2,

3,

4,

5} , Jing Liu _{1,

2,

3,

4,

5} , Jing-Juan Xu _{5,

6,

7,

8,

9} , Shu-Sheng Zhang _{1,

2,

3,

4,

5} , Hong-Yuan Chen _{5,

6,

7,

8,

9}

Affiliation

Modern optical detection technology plays a critical role in current clinical detection due to its high sensitivity and accuracy. However, higher requirements such as extremely high detection sensitivity have been put forward due to the clinical needs for the early finding and diagnosing of malignant tumors which are significant for tumor therapy. The technology of isothermal amplification with nucleic acids opens up avenues for meeting this requirement. Recent reports have shown that a nucleic acid amplification-assisted modern optical sensing interface has achieved satisfactory sensitivity and accuracy, high speed and specificity. Compared with isothermal amplification technology designed to work completely in a solution system, solid biosensing interfaces demonstrated better performances in stability and sensitivity due to their ease of separation from the reaction mixture and the better signal transduction on these optical nano-biosensing interfaces. Also the flexibility and designability during the construction of these nano-biosensing interfaces provided a promising research topic for the ultrasensitive detection of cancer diseases. In this review, we describe the construction of the burgeoning number of optical nano-biosensing interfaces assisted by a nucleic acid amplification strategy, and provide insightful views on: (1) approaches to the smart fabrication of an optical nano-biosensing interface, (2) biosensing mechanisms via the nucleic acid amplification method, (3) the newest strategies and future perspectives.

中文翻译：

通过核酸扩增策略的光学纳米生物传感界面：构建和应用

由于其高灵敏度和准确性，现代光学检测技术在当前的临床检测中起着至关重要的作用。但是，由于对早期发现和诊断对肿瘤治疗很重要的恶性肿瘤的临床需要，提出了更高的要求，例如极高的检测灵敏度。核酸等温扩增技术为满足这一要求开辟了道路。最近的报道表明，核酸扩增辅助的现代光学传感界面已经获得令人满意的灵敏度和准确性，高速和特异性。与旨在完全在溶液系统中工作的等温放大技术相比，固体生物传感界面由于易于从反应混合物中分离，并且在这些光学纳米生物传感界面上表现出更好的信号传导，因此在稳定性和灵敏性方面表现出更好的性能。这些纳米生物传感界面的构建过程中的灵活性和可设计性为癌症疾病的超灵敏检测提供了有前途的研究主题。在这篇综述中，我们描述了借助核酸扩增策略构建的新兴的光学纳米生物传感界面数量，并就以下方面提供了有见地的见解：（1）智能制造光学纳米生物传感界面的方法，（2 ）生物传感机制这些纳米生物传感界面的构建过程中的灵活性和可设计性为癌症疾病的超灵敏检测提供了有前途的研究主题。在这篇综述中，我们描述了借助核酸扩增策略构建的新兴的光学纳米生物传感界面数量，并就以下方面提供了有见地的见解：（1）智能制造光学纳米生物传感界面的方法，（2 ）生物传感机制这些纳米生物传感界面的构建过程中的灵活性和可设计性为癌症疾病的超灵敏检测提供了有前途的研究主题。在这篇综述中，我们描述了借助核酸扩增策略构建的新兴的光学纳米生物传感界面数量，并就以下方面提供了有见地的见解：（1）智能制造光学纳米生物传感界面的方法，（2 ）生物传感机制通过核酸扩增方法，（3）最新策略和未来展望。

更新日期：2018-02-15

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