Nerve agent-induced seizures can cause varying degrees of neuropathology depending on level of poisoning and duration of seizing. The intention of this review was to validate a novel approach for establishing effective treatment regimens against soman poisoning. Identification of seizure controlling sites in the forebrain of rats poisoned by soman was made by means of lesions, and the anticonvulsive properties of a number of relevant drugs were tested by microinfusions into the identified areas. By using these procedures, procyclidine emerged as the most potent drug. Its potency was confirmed in systemic studies and is further enhanced when combined with levetiracetam. Acute treatment with a combination of HI-6, levetiracetam and procyclidine (procyclidine regimen) can effectively manage supralethal poisoning by any of the classical nerve agents. Extended treatment with the procyclidine regimen is able to terminate residual “silent”, local epileptiform activity in the severely poisoned rats. Evident advantages are seen when the same regimen exerts both powerful anticonvulsant and neuroprotectant efficacies. According to the results presented, the new strategy for establishing therapies against soman-induced seizures appears to be valid.

神经毒剂引起的癫痫发作可引起中毒程度和发作持续时间不同程度的神经病理学改变。这篇综述的目的是验证一种新颖的方法，以建立针对索曼中毒的有效治疗方案。通过损伤的方法鉴定了被梭曼中毒的大鼠前脑中的癫痫发作控制部位，并通过向确定的部位进行微输注来测试了许多相关药物的抗惊厥特性。通过使用这些程序，环丙环啶出现为最有效的药物。其功效已在系统研究中得到证实，与左乙拉西坦联合使用后进一步增强。HI-6，左乙拉西坦和环丙啶（环丙啶方案）联合使用的急性治疗可以有效地治疗任何经典神经药物引起的ral上中毒。在严重中毒的大鼠中，用环丙啶方案进行的进一步治疗能够终止残留的“沉默”，局部癫痫样活动。当相同的方案同时发挥强大的抗惊厥和神经保护作用时，可以看到明显的优势。根据给出的结果，建立针对梭曼诱发的癫痫发作的治疗新策略似乎是有效的。