Articles appearing in Gastroenterology have played an integral role in the evolution of our understanding of Functional Bowel Disorders (FBD), including Irritable Bowel Syndrome (IBS), beginning with the prescient contributions of Almy and Tulin in 1947 and 1949 that highlighted the role of stress to enhance perception of abdominal pain and promote colon contractions. Subsequent publications have codified diagnostic criteria and stratified subpopulations of FBD (Manning and ROME I-IV), which resulted in improved symptom-based therapeutic interventions. Advances in our understanding of the pathophysiology of FBD, particularly IBS, published in Gastroenterology has led to our current appreciation that FBD represent dysfunction in the bidirectional brain-gut axis, intestinal barrier dysfunction and interactions with the microbiota and dietary factors. Team science and the application of next-generation -omics methods are leading the way to improved diagnostic criteria and targeted therapeutic interventions. As the field evolves, publications appearing in Gastroenterology will continue to be at the forefront of these advances.

胃肠病学文章对我们对功能性肠病（FBD）的理解起了不可或缺的作用，包括肠易激综合症（IBS），始于1947年和1949年Almy和Tulin的有先见之明，着重强调了压力的作用增强对腹痛的感知并促进结肠收缩。随后的出版物将诊断标准和FBD的亚人群分类（Manning和ROME I-IV），从而改善了基于症状的治疗干预措施。胃肠病学对FBD，尤其是IBS的病理生理学的理解的进步，导致我们目前的认识是，FBD代表双向脑肠轴功能障碍，肠屏障功能障碍以及与微生物群和饮食因素的相互作用。团队科学和下一代组学方法的应用正在引领改善诊断标准和针对性治疗干预的道路。随着该领域的发展，胃肠病学方面的出版物将继续处于这些进展的最前沿。