Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.

中文翻译：

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整合素促进神经系统损伤后轴突再生


整合素是细胞表面受体，形成细胞环境的细胞外基质分子与内部细胞信号传导和细胞骨架之间的联系。它们参与多个过程，例如发育和修复过程中的粘附和迁移。本综述重点关注整合素在轴突再生中的作用。整合素通过与抑制或增强其激活和信号传导的各种配体结合，参与周围神经系统的自发轴突再生。中枢神经系统中的整合素生物学更为复杂。整合素受体在发育过程中被转运到生长的轴突中，但整合素的选择性极化转运限制了成年神经元的再生反应。操纵整合素和相关分子来控制它们的激活状态和轴突内的定位是刺激中枢神经系统有效再生的一条有前途的途径。