Inert C–H Bond Transformations Enabled by Organometallic Manganese Catalysis,Accounts of Chemical Research

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Inert C–H Bond Transformations Enabled by Organometallic Manganese Catalysis
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1021/acs.accounts.8b00028
Yuanyuan Hu _{1,

2} , Bingwei Zhou _{1,

2} , Congyang Wang _{1,

2}

Affiliation

Traditional organic synthesis relies heavily on the transformations of various preinstalled functional groups, such as cross-coupling reactions using organohalides and organometallic reagents. The strategy of C–H activation enables the direct formation of C–C/C–X (X = heteroatom) bonds from inert C–H bonds, which can enhance the atom- and step-economy of organic synthesis. To date, precious metals have overwhelmingly dominated the C–H activation field; however, the rarity and high cost of these metals necessitate the development of more sustainable catalysts. In this regard, catalysts based on manganese are highly desirable owing to the abundant reserve of manganese in the earth’s crust and its economic benefits, low toxicity, and potentially unique reactivity. Although the first stoichiometric manganese-mediated C–H activation reaction was reported as early as 1970, manganese-catalyzed C–H activation reactions are largely underdeveloped. How to construct an efficient catalytic cycle for manganese in C–H activation reactions remains as a key issue to be addressed.

中文翻译：

有机金属锰催化实现的惰性CH键转换

传统的有机合成在很大程度上依赖于各种预先安装的官能团的转化，例如使用有机卤化物和有机金属试剂的交叉偶联反应。C–H活化策略可以从惰性C–H键直接形成C–C / C–X（X =杂原子）键，从而可以增强有机合成的原子经济和阶梯经济。迄今为止，贵金属已在CHH活化领域占绝对优势。然而，这些金属的稀有性和高成本使得必须开发更具可持续性的催化剂。在这方面，由于锰在地壳中的丰富储备及其经济效益，低毒性和潜在的独特反应性，因此非常需要基于锰的催化剂。尽管早在1970年就报道了第一个化学计量的锰介导的C–H活化反应，但锰催化的C–H活化反应在很大程度上尚不完善。如何为甲烷在C–H活化反应中建立有效的催化循环仍然是需要解决的关键问题。

更新日期：2018-02-14

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