当前位置：
X-MOL 学术
›
ChemMedChem
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy
ChemMedChem ( IF 3.6 ) Pub Date : 2018-03-07 , DOI: 10.1002/cmdc.201700762 Si S. Yuan 1 , Mao L. Li 1 , Jian S. Chen 2 , Li Zhou 3 , Wen Zhou 1
ChemMedChem ( IF 3.6 ) Pub Date : 2018-03-07 , DOI: 10.1002/cmdc.201700762 Si S. Yuan 1 , Mao L. Li 1 , Jian S. Chen 2 , Li Zhou 3 , Wen Zhou 1
Affiliation
|
Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono‐ or disaccharides. Galactose, mannose, fucose, glucose, sialic acid, etc., are commonly used as powerful scaffolds installed on drug molecules for targeting specific tissues including brain, liver, and cancers, and as epitopes for enhancing the targeting of various vaccines. This review focuses on the influence of their structural variations, including changes in sugar type, substituent groups and their positions, as well as length of linker portion, on the targeting of drugs or their efficacy. Particular attention is paid to the targeting properties of mono‐ and disaccharides applied in drug design and discovery.
中文翻译：
单糖和双糖在药物靶向和功效中的应用
碳水化合物及其结合物在许多生物过程中都发挥着重要作用，包括受精，分化，发育，免疫反应和感染。它们的活性在很大程度上取决于末端单糖或二糖的性质。半乳糖，甘露糖，岩藻糖，葡萄糖，唾液酸等通常用作安装在药物分子上的有力支架，以靶向特定组织，包括脑，肝和癌症，以及作为表位，以增强各种疫苗的靶向性。这篇综述着重于它们的结构变化对药物靶向或其功效的影响，包括糖类型，取代基及其位置的变化以及接头部分的长度。
更新日期：2018-03-07
中文翻译：
单糖和双糖在药物靶向和功效中的应用
碳水化合物及其结合物在许多生物过程中都发挥着重要作用，包括受精，分化，发育，免疫反应和感染。它们的活性在很大程度上取决于末端单糖或二糖的性质。半乳糖，甘露糖，岩藻糖，葡萄糖，唾液酸等通常用作安装在药物分子上的有力支架，以靶向特定组织，包括脑，肝和癌症，以及作为表位，以增强各种疫苗的靶向性。这篇综述着重于它们的结构变化对药物靶向或其功效的影响，包括糖类型，取代基及其位置的变化以及接头部分的长度。
京公网安备 11010802027423号