Hexafluorosilicate salts of the antidepressant drugs Paroxetine (PRX) and Fluoxetine (FLX), [PRX]₂SiF₆ and [FLX]₂SiF₆⋅H₂O, are investigated herein by SCXRD, Hirshfeld surface analysis, and Infrared spectroscopy. By their crystal structures, it is possible to observe, for the first time, at least at the best of our knowledge, the formation of a supramolecular architecture of the [SiF₆]²⁻ anion with protonated secondary amine groups. The [PRX]₂SiF₆ crystallizes in the P2₁ space group and the [FLX]2SiF₆⋅H₂O in the P2₁/c, as a hydrate racemate. While two conformers are present in the asymmetric unit of [PRX]₂SiF₆, two enantiomers enclose the one of [FLX]₂SiF₆⋅H₂O. Analysis of the crystal packing show that NHFSi (1.94–2.42 Ǻ), CHFSi (2.36–2.62 Å), and CHπ interactions are the main contributors toward the supramolecular architectures in these salts.

抗抑郁药帕罗西汀（PRX）和氟西汀（FLX）的六氟硅酸盐，[PRX] ₂的SiF ₆和[FLX] ₂的SiF ₆ ⋅H ₂ O，通过SCXRD，Hirshfeld表面分析和红外光谱本文调查。通过它们的晶体结构，至少在我们所知的范围内，首次可以观察到具有质子化仲胺基团的[SiF ₆ ] ^2-阴离子的超分子结构的形成。的[PRX] ₂的SiF _6个结晶中P2 ₁空间群和[FLX] 2SIF ₆ ⋅H ₂中的OP2 ₁ / c，为水合物消旋体。虽然两种构象异构存在于的不对称单元[PRX] ₂的SiF ₆，两个对映体包围的一个[FLX] ₂的SiF ₆ ⋅H ₂的晶体堆积显示O.分析N个HF的Si（1.94-2.42Ǻ） ，C HF Si（2.36-2.62Å）和CHπ相互作用是这些盐中超分子结构的主要贡献者。