Abstract In this study quaternary bioglass system (BG) SiO 2 –CaO–Na 2 O–P 2 O 5 doped with Fe 2 O 3 was prepared by the sol–gel method. Furthermore, 3D scaffolds were designed through blending Fe 2 O 3 -doped bioglass with chitosan to obtain various compositions of scaffolds by the freeze-drying technique. The thermal behavior, morphological properties, porosity (%), mechanical properties and physicochemical properties of BG and scaffolds were evaluated by DSC/TGA, TEM, SEM, liquid displacement method, universal testing machine, XRD and FTIR. In addition, the in vitro bioactivity of the prepared scaffolds was studied in phosphate buffer saline (PBS) through the determination of PBS ions concentrations, as well as the degradation and the observation of precipitated calcium phosphate layer by SEM coupled with EDX and FTIR behavior. The cell viability of the prepared scaffolds was conducted against Baby Hamster Kidney fibroblasts (BHK-21) cell line. The presence of Fe 2 O 3 decreased the T g (from 513 to 390 °C) and the size decreased (from 20.89 to 50.81–13.92–27.87 nm). The scaffolds porosity (%) decreased upon Fe 2 O 3 doping but the mechanical strength increased. Cell viability results for the designed scaffolds demonstrated acceptable cell viability compared with normal cells. Therefore, the designed scaffolds are promoted as regenerated materials that can be used for bone tissue replacement.

中文翻译：

---

用于骨组织置换的新型 Fe 2 O 3 掺杂玻璃/壳聚糖支架

摘要 在本研究中，通过溶胶-凝胶法制备了掺杂有 Fe 2 O 3 的四元生物玻璃系统 (BG) SiO 2 -CaO-Na 2 O-P 2 O 5 。此外，通过将 Fe 2 O 3 掺杂的生物玻璃与壳聚糖混合，通过冷冻干燥技术获得各种组成的支架，设计了 3D 支架。通过DSC/TGA、TEM、SEM、液体置换法、万能试验机、XRD和FTIR对BG和支架的热行为、形态学性能、孔隙率(%)、力学性能和理化性能进行了评价。此外，通过测定PBS离子浓度，以及SEM结合EDX和FTIR行为对沉淀的磷酸钙层的降解和观察，研究了制备的支架在磷酸盐缓冲盐水（PBS）中的体外生物活性。针对婴儿仓鼠肾成纤维细胞 (BHK-21) 细胞系对制备的支架进行细胞活力。Fe 2 O 3 的存在降低了 T g （从 513 到 390 °C）并且尺寸减小（从 20.89 到 50.81–13.92–27.87 nm）。Fe 2 O 3 掺杂后支架孔隙率（%）降低，但机械强度增加。与正常细胞相比，设计的支架的细胞活力结果证明了可接受的细胞活力。因此，设计的支架被推广为可用于骨组织置换的再生材料。Fe 2 O 3 掺杂后支架孔隙率（%）降低，但机械强度增加。与正常细胞相比，设计的支架的细胞活力结果证明了可接受的细胞活力。因此，设计的支架被推广为可用于骨组织置换的再生材料。Fe 2 O 3 掺杂后支架孔隙率（%）降低，但机械强度增加。与正常细胞相比，设计的支架的细胞活力结果证明了可接受的细胞活力。因此，设计的支架被推广为可用于骨组织置换的再生材料。