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pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1021/acs.biomac.7b01590 Lindsey A. Sharpe , Julia E. Vela Ramirez , Olivia M. Haddadin , Kathleen A. Ross 1 , Balaji Narasimhan 1 , Nicholas A. Peppas
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1021/acs.biomac.7b01590 Lindsey A. Sharpe , Julia E. Vela Ramirez , Olivia M. Haddadin , Kathleen A. Ross 1 , Balaji Narasimhan 1 , Nicholas A. Peppas
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Multicompartmental polymer carriers, referred to as Polyanhydride-Releasing Oral MicroParticle Technology (PROMPT), were formed by a pH-triggered antisolvent precipitation technique. Polyanhydride nanoparticles were encapsulated into anionic pH-responsive microparticle gels, allowing for nanoparticle encapsulation in acidic conditions and subsequent release in neutral pH conditions. The effects of varying the nanoparticle composition and feed ratio on the encapsulation efficiency were evaluated. Nanoparticle encapsulation was confirmed by confocal microscopy and infrared spectroscopy. pH-triggered protein delivery from PROMPT was explored using ovalbumin (ova) as a model drug. PROMPT microgels released ova in a pH-controlled manner. Increasing the feed ratio of nanoparticles into the microgels increased the total amount of ova delivered, as well as decreased the observed burst release. The cytocompatibility of the polymer materials were assessed using cells representative of the GI tract. Overall, these results suggest that pH-dependent microencapsulation is a viable platform to achieve targeted intestinal delivery of polyanhydride nanoparticles and their payload(s).
中文翻译：
pH响应的微囊化系统，用于口服递送聚酸酐纳米颗粒。
通过pH触发的反溶剂沉淀技术形成了多隔室聚合物载体，称为聚酸酐释放口腔微粒技术（PROMPT）。将聚酸酐纳米颗粒封装到阴离子pH响应微粒凝胶中，从而可以在酸性条件下封装纳米颗粒，并随后在中性pH条件下释放。评价了改变纳米颗粒组成和进料比对包封效率的影响。通过共聚焦显微镜和红外光谱确认了纳米颗粒的包封。使用卵清蛋白（ova）作为模型药物探索了pH触发的从PROMPT释放的蛋白质。PROMPT微凝胶以pH值控制的方式释放卵。增加纳米颗粒进入微凝胶的进料比，可以增加所输送卵子的总量，并减少了观察到的爆发释放。使用代表胃肠道的细胞评估聚合物材料的细胞相容性。总体而言，这些结果表明，pH依赖的微囊化是实现聚酸酐纳米颗粒及其有效载荷靶向肠递送的可行平台。
更新日期：2018-02-14
中文翻译：
pH响应的微囊化系统，用于口服递送聚酸酐纳米颗粒。
通过pH触发的反溶剂沉淀技术形成了多隔室聚合物载体，称为聚酸酐释放口腔微粒技术（PROMPT）。将聚酸酐纳米颗粒封装到阴离子pH响应微粒凝胶中，从而可以在酸性条件下封装纳米颗粒，并随后在中性pH条件下释放。评价了改变纳米颗粒组成和进料比对包封效率的影响。通过共聚焦显微镜和红外光谱确认了纳米颗粒的包封。使用卵清蛋白（ova）作为模型药物探索了pH触发的从PROMPT释放的蛋白质。PROMPT微凝胶以pH值控制的方式释放卵。增加纳米颗粒进入微凝胶的进料比，可以增加所输送卵子的总量，并减少了观察到的爆发释放。使用代表胃肠道的细胞评估聚合物材料的细胞相容性。总体而言，这些结果表明，pH依赖的微囊化是实现聚酸酐纳米颗粒及其有效载荷靶向肠递送的可行平台。
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