当前位置:
X-MOL 学术
›
Acc. Chem. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1021/acs.accounts.7b00250 John A. Carver 1 , Heath Ecroyd 2 , Roger J. W. Truscott 2 , David C. Thorn 1 , Carl Holt 3
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1021/acs.accounts.7b00250 John A. Carver 1 , Heath Ecroyd 2 , Roger J. W. Truscott 2 , David C. Thorn 1 , Carl Holt 3
Affiliation
Molecular chaperone proteins perform a diversity of roles inside and outside the cell. One of the most important is the stabilization of misfolding proteins to prevent their aggregation, a process that is potentially detrimental to cell viability. Diseases such as Alzheimer’s, Parkinson’s, and cataract are characterized by the accumulation of protein aggregates.
中文翻译:
蛋白水解和ATP独立的分子伴侣对内和细胞外蛋白质聚集的调节:晶状体α-结晶蛋白和酪蛋白
分子伴侣蛋白在细胞内外具有多种作用。最重要的一项是稳定错误折叠的蛋白质,以防止其聚集,这一过程可能会损害细胞的生存能力。诸如阿尔茨海默氏病,帕金森氏病和白内障等疾病的特征在于蛋白质聚集体的积累。
更新日期:2018-02-14
中文翻译:
蛋白水解和ATP独立的分子伴侣对内和细胞外蛋白质聚集的调节:晶状体α-结晶蛋白和酪蛋白
分子伴侣蛋白在细胞内外具有多种作用。最重要的一项是稳定错误折叠的蛋白质,以防止其聚集,这一过程可能会损害细胞的生存能力。诸如阿尔茨海默氏病,帕金森氏病和白内障等疾病的特征在于蛋白质聚集体的积累。