Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation,ChemBioChem

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Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation
ChemBioChem ( IF 2.6 ) Pub Date : 2018-04-06 , DOI: 10.1002/cbic.201800002
Rebecca L Hancock ₁ , Martine I Abboud ₁ , Tristan J Smart ₁ , Emily Flashman ₁ , Akane Kawamura ₁ , Christopher J Schofield ₁ , Richard J Hopkinson _{1,

2}

Affiliation

Keeping active: The JmjC histone lysyl demethylases (KDMs) play important roles in modulating histone methylation states and have the potential to be regulated by oxygen availability. Biochemical analyses reveal that Lys241 in KDM4 promotes the coupling of 2‐oxoglutarate oxidation with demethylation activity, thus ensuring efficient catalysis and avoiding enzyme inactivation.

中文翻译：

在 KDM4 催化的组蛋白去甲基化过程中，赖氨酸-241 在 2OG 转换与底物氧化耦合中发挥作用

保持活跃：JmjC 组蛋白赖氨酰脱甲基酶 (KDM) 在调节组蛋白甲基化状态中发挥着重要作用，并且有可能受到氧气可用性的调节。生化分析表明，KDM4 中的 Lys241 促进 2-酮戊二酸氧化与去甲基化活性的偶联，从而确保有效的催化并避免酶失活。

更新日期：2018-04-06

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