The assessment of the suitability of novel targets to intervention by different modalities, e.g. small molecules or antibodies, is increasingly seen as important in helping to select the most progressable targets at the outset of a drug discovery project. This perspective considers differing aspects of tractability and how it can be assessed using in silico and experimental approaches. We also share some of our experiences in using these approaches.

中文翻译：

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目标易处理性评估的方法–实用的观点†

在药物发现项目开始之初，评估新型靶标是否适合通过不同方式（例如小分子或抗体）进行干预的评估就越来越重要，这有助于其选择最具发展潜力的靶标。这种观点考虑了易处理性的不同方面，以及如何使用计算机技术和实验方法对其进行评估。我们还分享了使用这些方法的一些经验。