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In situ photo-patterning of pressure-resistant hydrogel membranes with controlled permeabilities in PEGDA microfluidic channels†
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-02-14 00:00:00 , DOI: 10.1039/c7lc01342f
Jérémy Decock 1, 2, 3, 4, 5 , Mathias Schlenk 6, 7, 8, 9 , Jean-Baptiste Salmon 1, 2, 3, 4, 5
Affiliation  

We report the fabrication of highly permeable membranes in poly(ethylene glycol) diacrylate (PEGDA) channels, for investigating ultra- or micro-filtration, at the microfluidic scale. More precisely, we used a maskless UV projection setup to photo-pattern PEG-based hydrogel membranes on a large scale (mm–cm), and with a spatial resolution of a few microns. We show that these membranes can withstand trans-membrane pressure drops of up to 7 bar without any leakage, thanks to the strong anchoring of the hydrogel to the channel walls. We also report in situ measurements of the Darcy permeability of these membranes, as a function of the deposited energy during photo-polymerization, and their formulation composition. We show that the use of PEG chains as porogens, as proposed in [Lee et al., Biomacromolecules, 2010, 11, 3316], significantly increases the porosity of the hydrogels, up to Darcy permeabilities of about 1.5 × 10−16 m2, while maintaining the strong mechanical stability of the membranes. We finally illustrate the opportunities offered by this technique, by investigating frontal filtration of colloidal dispersions in a straight microfluidic channel.

中文翻译:

PEGDA微流体通道中具有受控渗透率的耐压水凝胶膜的原位光成像

我们报告在聚(乙二醇)二丙烯酸酯(PEGDA)通道中制造高渗透性的膜,用于研究微流体规模的超滤或微滤。更准确地说,我们使用无掩模UV投影装置以大尺寸(mm-cm)且具有几微米的空间分辨率对基于PEG的水凝胶膜进行光图案化。我们表明,这些膜可以承受的反式高达7巴的-membrane压降无任何泄漏,由于水凝胶的通道壁的强锚定。我们还报告了这些膜的达西渗透率的原位测量结果,它们是光聚合过程中沉积能量及其制剂组成的函数。我们证明了使用PEG链作为致孔剂,如[Lee等。生物大分子,2010,11,3316],显著增加了水凝胶的孔隙率,高达约1.5×10达西的渗透率-162,同时保持了膜的强机械稳定性。最后,我们通过研究在直的微流体通道中对胶体分散体进行正面过滤来说明这种技术提供的机会。
更新日期:2018-02-14
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