Programmable surface-patterned functional DNA density is achieved via manipulation of molecular-level defects through chemical lift-off lithography. Artificial SAM defects are well-tunable by a contact-induced reaction, enabling molecular environment guidance and DNA insertion to be spatially and quantitatively addressable. This straightforward molecular density control creates an advanced avenue toward fabricating multiplexed bioactive substrates.

中文翻译：

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通过可编程的分子缺陷控制表面功能性DNA密度†

通过化学剥离光刻技术对分子水平的缺陷进行处理，可获得可编程的表面图案化功能性DNA密度。人造SAM缺陷可通过接触诱导的反应很好地调节，使分子环境指导和DNA插入在空间和数量上都可解决。这种直接的分子密度控制为制造多重生物活性底物创造了先进的途径。