Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines,Chemical Communications

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Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines
Chemical Communications ( IF 4.3 ) Pub Date : 2018-02-13 00:00:00 , DOI: 10.1039/c8cc00485d
Zaifeng Yuan _{1,

2,

3,

4,

5} , Na Li _{6,

7,

8,

9,

10} , Chunyu Zhu _{6,

7,

8,

9,

10} , Chengfeng Xia _{1,

2,

3,

4,

5}

Affiliation

A copper-catalyzed activation of C(sp³)–H bonds of DMF at room temperature was developed, which results in methyl transfer to aromatic amines for efficient synthesis of exceedingly valuable α-amino nitriles. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.

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