Serotonergic psychedelics act as agonists at cortical 5-HT_2A receptors and seem to induce personality changes. We conducted a systematic review of studies assessing the effects of these drugs on personality. Papers published from 1985–2016 were included from PubMed, LILACS, and SciELO databases. Three hundred and sixty-nine studies were identified, and 18 were included. Specific personality traits, such as Absorption and Self-Transcendence, seem to influence the effects of psychedelics, and psychedelic drug users and nonusers appear to differ in some personality traits. Psychedelics administered in controlled settings may induce personality changes, such as increased Openness and Self-Transcendence. Increases in global brain entropy induced by acute psychedelic administration predicted changes in Openness, and Self-Transcendence was negatively correlated with cortical thinning of the posterior cingulate cortex in long-term religious ayahuasca users. Acute and long-term use of psychedelics is associated with personality changes that appear to be modulated by 5-HT_2A receptors. These changes seem to induce therapeutic effects that should be further explored in randomized controlled studies.

血清素能的迷幻药在皮质5-HT _2A中起激动剂的作用受体并似乎诱发人格改变。我们对评估这些药物对人格的影响的研究进行了系统的综述。1985-2016年发表的论文均来自PubMed，LILACS和SciELO数据库。确定了369项研究，其中包括18项。诸如吸收和自我超越之类的特定人格特质似乎会影响迷幻药的效果，而迷幻药的吸毒者和非吸毒者在某些人格特质上似乎有所不同。在控制的环境中服用迷幻药可能会导致人格改变，例如开放性和自我超越感增强。急性迷幻药引起的全脑熵增加预示着开放性的变化，在长期宗教阿育吠陀使用者中，自我超越与后扣带回皮质的皮质变薄呈负相关。长期长期使用迷幻药会导致人格改变，这些人格改变似乎是由5-HT调节的_2A受体。这些变化似乎诱导了治疗效果，应在随机对照研究中进一步探讨。