The Solid–Liquid Equilibrium and Crystal Habit of l-Carnitine Fumarate,Journal of Chemical & Engineering Data

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The Solid–Liquid Equilibrium and Crystal Habit of l-Carnitine Fumarate
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2018-02-13 00:00:00 , DOI: 10.1021/acs.jced.7b00768
Yun Cao _{1,

2} , Shiyuan Liu _{1,

2} , Shichao Du _{1,

2} , Yumin Liu _{1,

2} , Yingdan Cui _{1,

2} , Xiaona Li _{1,

2} , Dandan Han _{1,

2} , Junbo Gong _{1,

2}

Affiliation

The solid–liquid equilibrium data of l-carnitine fumarate in methanol + (ethanol/1-propanol/2-propanol) binary mixed systems were determined at temperatures ranging from 288.15 to 328.15 K, while the solubility data of l-carnitine fumarate in (methanol +1-butanol) mixtures were determined from T = (293.15 to 333.15) K because of its low solubility in low temperature. All experimental data were obtained by the gravimetric method under atmospheric pressure. At each composition point, the data increases with the increasing temperature in all determined solutions. A similar trend is also observed when the mole fraction of methanol increases in all binary solvent mixtures for each temperature. It is also found that the solubility data of l-carnitine fumarate in these binary mixtures rank as (methanol + ethanol) > (methanol +1-propanol) > (methanol +2-propanol) > (methanol +1-butanol). The modified Apelblat equation, (CNIBS)/Redlich–Kister model, Solubility–Polarity model, and Jouyban–Acree model were employed to correlate the solubility data determined, and all of them show good agreement with experimental value. Furthermore, the crystal morphology and size distribution of l-carnitine fumarate in different solvents was studied in order to select favorable solvents for good crystal habits.

中文翻译：

肉碱富马酸酯的固液平衡和晶体习性

的固-液平衡数据升甲醇+（乙醇/ 1-丙醇/ 2-丙醇）在温度为288.15到328.15 K含量确定二元混合系统肉碱富马酸盐，而中的溶解度数据升在肉碱富马酸盐（由于其在低温下的低溶解度，因此从T =（293.15至333.15）K确定了甲醇+ 1-丁醇）的混合物。所有实验数据均通过重量法在大气压下获得。在每个组成点，所有确定的溶液中的数据都随着温度的升高而增加。当在每个温度下所有二元溶剂混合物中甲醇的摩尔分数增加时，也观察到类似的趋势。还发现l的溶解度数据这些二元混合物中的-富马酸肉碱等级为（甲醇+乙醇）>（甲醇+ 1-丙醇）>（甲醇+ 2-丙醇）>（甲醇+ 1-丁醇）。修改后的Apelblat方程（CNIBS）/ Redlich–Kister模型，Solubility–Polarity模型和Jouyban–Acree模型用于关联确定的溶解度数据，它们均与实验值具有良好的一致性。此外，晶体的形态和尺寸分布升肉碱富马酸盐在不同的溶剂，以便选择为良好的晶体习性有利的溶剂进行了研究。

更新日期：2018-02-14

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