From Synthesis of Amino Acids and Peptides to Enzymatic Catalysis: A Bottom‐Up Approach in Mechanochemistry,ChemSusChem

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From Synthesis of Amino Acids and Peptides to Enzymatic Catalysis: A Bottom‐Up Approach in Mechanochemistry
ChemSusChem ( IF 7.5 ) Pub Date : 2018-03-30 , DOI: 10.1002/cssc.201800113
Carsten Bolm ₁ , José G. Hernández ₁

Affiliation

Recently, chemical reactions induced or facilitated by mechanical energy have gained recognition in diverse areas of chemical synthesis. In particular, mechanosyntheses of amino acids and short peptides, along with their applications in catalysis, have revealed the high degree of stability of peptide bonds in environments of harsh mechanical stress. These observations quickly led to the recent interest in developing mechanochemical enzymatic reactions. Experimentally, manual grinding, ball‐milling techniques, and twin‐screw extrusion technology have proven valuable to convey mechanical forces into a chemical synthesis. These practices have enabled the establishment of more sustainable alternatives for chemical synthesis by reducing the use of organic solvents and waste production, thereby having a direct impact on the E‐factor of the chemical process. In this Minireview, the series of events that allowed the development of mechanochemical enzymatic reactions are described from a bottom‐up perspective.

中文翻译：

从氨基酸和多肽的合成到酶催化：机械化学的自下而上方法

最近，由机械能诱导或促进的化学反应已在化学合成的各个领域得到认可。特别地，氨基酸和短肽的机械合成及其在催化中的应用揭示了在苛刻的机械应力环境中肽键的高度稳定性。这些观察很快引起了最近对发展机械化学酶促反应的兴趣。在实验上，事实证明，手动研磨，球磨技术和双螺杆挤出技术对于将机械力传递到化学合成中非常有价值。这些做法通过减少有机溶剂的使用和废物的产生，为化学合成建立了更可持续的替代方法，从而直接影响化学过程的E因子。在此Minireview中，从下至上的角度描述了一系列允许发生机械化学酶促反应的事件。

更新日期：2018-03-30

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