A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy†,Journal of Materials Chemistry B

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A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-02-13 00:00:00 , DOI: 10.1039/c8tb00087e
Si Chen _{1,

2,

3,

4} , Jinxuan Fan _{4,

5,

6,

7} , Wenxiu Qiu _{4,

5,

6,

7} , Fan Liu _{1,

2,

3,

4} , Guoping Yan _{1,

2,

3,

4} , Xuan Zeng _{4,

5,

6,

7} , Xianzheng Zhang _{4,

5,

6,

7}

Affiliation

In this work, a cellular/intranuclear dual-targeting nanoplatform was designed for tumor photothermal therapy (PTT). As a photo-to-heat nanoheater, a gold nanostar (GNS) was decorated with a nuclear localization sequence (NLS) to form GNS-NLS which possessed nuclear-targeting ability. After that, hyaluronic acid (HA) was coated on the surface of GNS-NLS (GNS-NLS@HA) via electrostatic interaction for tumor cellular recognition and targeting. It was found that by harnessing the recognition of CD44 receptor by HA, GNS-NLS@HA had the ability to target tumor cells accurately, and further be efficaciously internalized into cells with stellate shape. Subsequently, tumor intracellular hyaluronidase (HAase) from the endosome led to the degradation of HA to expose nuclear-targeting nanoheater GNS-NLS, and GNS-NLS was able to enhance PTT efficiency through subcellular nuclear location by a dual-stage near infrared light irradiation strategy. The first stage of light irradiation was of short duration to enhance the subcellular location of the nanoplatform to nuclei, and the second stage of light irradiation was of long duration to achieve admirable photothermal transduction as well as destruction of nuclei. This cellular/intranuclear dual-targeting nanoplatform, GNS-NLS@HA, displayed prominent tumor suppression efficiency both in vitro and in vivo, and inhibited tumor metastasis effectively.

中文翻译：

基于金纳米星的细胞/核双靶向纳米平台，用于精确的肿瘤光热疗法†

在这项工作中，为肿瘤光热疗法（PTT）设计了一种细胞/核双靶向纳米平台。作为光热纳米加热器，用核定位序列（NLS）装饰了金纳米星（GNS），形成了具有核靶向能力的GNS-NLS。之后，将透明质酸（HA）涂在GNS-NLS（GNS-NLS @ HA）的表面上用于肿瘤细胞识别和靶向的静电相互作用。发现通过利用HA对CD44受体的识别，GNS-NLS @ HA具有准确靶向肿瘤细胞的能力，并且被有效地内化成星状形状的细胞。随后，来自内体的肿瘤细胞内透明质酸酶（HAase）导致HA降解，从而暴露出靶向核的纳米加热器GNS-NLS，并且GNS-NLS能够通过双阶段近红外光照射通过亚细胞核定位来提高PTT效率。战略。光照射的第一阶段持续时间短，以增强纳米平台在细胞核中的亚细胞定位，光照射的第二阶段持续时间长，以实现令人称赞的光热传导以及细胞核的破坏。在体外和体内，并抑制肿瘤的转移有效。

更新日期：2018-02-13

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